polymorphism of smad7 gene (rs2337104) and risk of colorectal cancer in an iranian population: a case-control study
نویسندگان
چکیده
aim: the purpose of this study was to evaluate the influence of intronic polymorphism of the smad7 (mothers against decantaplegic homolog 7) gene (rs2337104) on the risk of colorectal cancer (crc) and clinicopathological features in an iranian population background : smad7 has been identified as an antagonist of transforming growth factor beta (tgf-b)-mediating fibrosis, carcinogenesis, and inflammation. regarding to the recent genome-wide scan, a risk locus for colorectal cancer at 18q21 has been found, which maps to the smad7 gene. methods : this case-control study was performed on 109 crc patients and 109 healthy controls recruited in taleghani hospital. the genotyping of all samples were done by taqman assay via an abi 7500 real time pcr system (applied biosystems) with dna from peripheral blood. the association of this polymorphism with the risk of crc and clinicopathological features was investigated. results: our results indicated that there were no any significant association between genotypic and allelic frequencies of smad7 polymorphism (rs2337104) and crc risk in our population. although the t allele is the most frequent one in this population and its frequency was 86.7% in patients compared with 91.7% in controls (or=1.705, 95% ci= 0.916 -3.172). also the smad7 genotypes were not associated with any clinicopathological characteristics in crc patients (p value >0.05). conclusion: for the first time, this study results revealed that this smad7 polymorphism couldn’t be a potential risk factor for crc or a prognostic biomarker for prediction of clinicopathological features in an iranian population. a large-scale case-control study is needed to validate our results. key words: smad7, colorectal cancer, single nucleotide polymorphism
منابع مشابه
Polymorphism of SMAD7 gene (rs2337104) and risk of colorectal cancer in an Iranian population: a case-control study
AIM The purpose of this study was to evaluate the influence of intronic polymorphism of the SMAD7 (Mothers Against Decantaplegic Homolog 7) gene (rs2337104) on the risk of colorectal cancer (CRC) and clinicopathological features in an Iranian population. BACKGROUND SMAD7 has been identified as an antagonist of transforming growth factor beta (TGF-b)-mediating fibrosis, carcinogenesis, and inf...
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Lack of Influence of SMAD7 Gene rs2337107 Polymorphism on the Risk of Colorectal Cancer in an Iranian Population
Colorectal cancer (CRC) as the third most common cancer brings about the fourth cause of worldwide cancer mortality (Jemal et al., 2011; Shemirani et al., 2011). According on World Health Organization (WHO) reports, CRC is one of the common diseases in an Asian population (Moghimi-Dehkordi et al., 2012; Haerian et al., 2014). It is noticeable that incidence of this cancer has been rising in an ...
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عنوان ژورنال:
gastroenterology and hepatology from bed to benchجلد ۷، شماره ۴، صفحات ۲۰۱۴-۷
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